Effect of Dapagliflozin on Klotho Protein and Renal Function in Elderly Patients with Diabetic Kidney Disease
10.11969/j.issn.1673-548X.2024.05.029
- VernacularTitle:达格列净对老年糖尿病肾病患者Klotho蛋白及肾功能的影响
- Author:
Xin DING
1
;
Yan JI
;
Chun NING
Author Information
1. 221004 徐州医科大学研究生院
- Keywords:
Dapagliflozin;
Elderly;
Diabetic kidney disease;
Klotho protein;
Renal function
- From:
Journal of Medical Research
2024;53(5):144-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of dapagliflozin on Klotho protein and renal function in elderly patients with diabetic kidney disease(DKD),and explore the related factors affecting the level of Klotho protein.Methods A total of 88 elderly DKD patients admitted to the Affiliated Hospital of Xuzhou Medical University from January 2021 to November 2021 were randomly divided into dapagli-flozin group and control group.The patients were treated for 12 weeks.The body weight,blood pressure,blood glucose,Klotho protein,renal function,urinary albumin/creatinine(UACR)were estimated before and after treatment,respectively,and adverse reactions were recorded.Results After treatment,the decrease degree of body weight,body mass index,systolic blood pressure,diastolic blood pres-sure,blood urea nitrogen(BUN),serum uric acid,cystatin C,UACR and the increase degree of Klotho protein were greater in dapagli-flozin group than those in the control group(P＜0.001).Multiple linear regression analysis showed that age,BUN and UACR were inde-pendent related factors affecting the level of Klotho protein.There was no significant difference in adverse events between the two groups(P＞0.05).Conclusion Dapagliflozin treatment can reduce body weight,blood pressure,improve renal function and increase the level of Klotho protein.The regulatory effect of dapagliflozin on Klotho protein may be one of the important mechanisms of its renal protection.
