Effects of Different Drugs on Cell Proliferation of Chronic Myeloid Leukemia
10.11969/j.issn.1673-548X.2024.05.014
- VernacularTitle:不同药物对慢性髓系白血病细胞增殖的影响
- Author:
Yan WANG
1
;
Xiaoling WANG
;
Guoqing LV
Author Information
1. 453100 新乡医学院第一附属医院血液内科
- Keywords:
Chronic myeloid leukemia;
Cell proliferation;
Combined index
- From:
Journal of Medical Research
2024;53(5):63-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of flumatinib,decitabine,arsenic trioxide and venetoclax on the proliferation of K562 cell line in human chronic myeloid leukemia(CML),and provide laboratory basis for new treatment options for CML.Methods Differ-ent concentrations of flumatinib,decitabine,arsenic trioxide,and venetoclax were used to treat on K562 cells alone or in combination.The cell proliferation activity was determined by CCK8method,and the combined index of the two drugs was calculated by Compusyn soft-ware.Results Different concentrations of flumatinib,arsenic trioxide,decitabine and venetoclax alone could inhibit the proliferation of K562 cells,and the differences were statistically significant(P＜0.01);The combination of two drugs with flumatinib,decitabine and ar-senic trioxide could enhance the inhibition effect on K562 cells(P＜0.01),but the combination with venetoclax was not significantly en-hancement on the inhibition effect on K562 cells(P＞0.05).Conclusion Flumatinib,arsenic trioxide,decitabine,and venetoclax a-lone can inhibit the proliferation of K562 cells,and the combination of two drugs with flumatinib,decitabine,and arsenic trioxide has syn-ergistic effect.There was no obvious synergistic effect between the three drugs combined with venetoclax,respectively.
