Expression and Significance of PPIB in Glioma
10.11969/j.issn.1673-548X.2024.05.007
- VernacularTitle:亲环蛋白B在脑胶质瘤中的表达及意义
- Author:
Xianzhe ZHOU
1
;
Xiangming HAN
;
Junwen ZHANG
Author Information
1. 100070 首都医科大学、北京市神经外科研究所、首都医科大学附属北京天坛医院
- Keywords:
Glioma;
Cydophilin B;
The Cancer Genome Atlas
- From:
Journal of Medical Research
2024;53(5):27-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of cyclophilin B(PPIB)in glioma and clinicopatholog-ical features,patient survival,and the infiltration of tumor-associated macrophages.Methods Based on the Cancer Genome Atlas(TCGA)database,the expression of PPIB in normal,low-grade,and high-grade gliomas was compared,and the expression of PPIB in glioma pathological tissues was detected by immunohistochemical staining.Based on the clinical case data of TCGA database,the relation-ship between PPIB expression and clinicopathological features of glioma was analyzed.Kaplan-Meier method was used to evaluate the im-pact of PPIB expression differences on the survival of glioma patients.Immunofluorescence method was used to analyze the expression of PPIB in the pathological tissues of glioma and its correlation with the infiltration of tumor-associated macrophages.Results The expres-sion of PPIB in high-grade glioma was significantly higher than that in normal tissue and low-grade glioma;PPIB was significantly cor-related with glioma grade,IDH wild type,and 1p/19q non-co-deletion(P＜0.001).The overall survival and progression-free inter-val of patients with high expression of PPIB were lower than those of patients with low expression of PPIB.In addition to the elevated ex-pression of PPIB in the pathological tissues of high-grade glioma,the high-expression area of PPIB was accompanied by a large number of tumor-associated macrophage infiltration.Conclusion Compared with low-grade gliomas,the expression levels of PPIB were higher in high-grade gliomas,and there were significant tumor-associated macrophage infiltration in PPIB-expressing areas.It is suggested that PPIB may serve as an independent prognostic factor for patients with glioma,providing reference for the prognosis of patients judg-ment.
