Association between Metformin Therapy and Breast Cancer Incidence and Mortality: Evidence from a Meta-Analysis.
10.4048/jbc.2015.18.3.264
- Author:
Ting YANG
1
;
Yuan YANG
;
Shengchun LIU
Author Information
1. Department of Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. liushengchun1968@126.com
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Breast neoplasms;
Meta-analysis;
Metformin;
Risk assessment
- MeSH:
Breast Neoplasms*;
Breast*;
Diabetes Mellitus, Type 2;
Humans;
Incidence*;
Metformin*;
Mortality*;
Publication Bias;
Risk Assessment
- From:Journal of Breast Cancer
2015;18(3):264-270
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Metformin may be associated with a decreased risk of breast cancer. We performed a meta-analysis to assess the effect of metformin intake on breast cancer risk and mortality. METHODS: We performed a PubMed and EMbase search for all available studies that described the risk of breast cancer and all-cause mortality in relation to the use of metformin among patients with type 2 diabetes mellitus. Pooled relative risks (RRs) were determined using a random effects model to assess the strength of association between metformin and the risk of breast cancer. RESULTS: Fifteen articles from PubMed satisfied the inclusion criteria, including a total of 838,333 participants. Compared with the control group, metformin use was not related to a reduced incidence of breast cancer (RR, 0.964; 95% confidence interval [CI], 0.761-1.221; p=0.761). However, metformin therapy was associated with decreased all-cause mortality (RR, 0.652; 95% CI, 0.488-0.873; p=0.004). No obvious publication bias was detected (incidence: p(Begg)=0.755, p(Egger)=0.008; mortality: p(Begg)=0.072, p(Egger)=0.185). CONCLUSION: The present study suggested that metformin therapy may decrease the all-cause mortality of patients affected by breast cancer. However, this finding should be considered carefully and confirmed with further studies.
