18F-FDG Positron-Emission Tomography/Computed Tomography Findings of Radiographic Lesions Suggesting Old Healed Tuberculosis.
10.3346/jkms.2014.29.3.386
- Author:
Yun Jeong JEONG
1
;
Jin Chul PAENG
;
Hyun Yeol NAM
;
Ji Sun LEE
;
Sang Min LEE
;
Chul Gyu YOO
;
Young Whan KIM
;
Sung Koo HAN
;
Jae Joon YIM
Author Information
1. Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Positron-Emission Tomography;
Tomography, X-Ray Computed;
Tuberculosis, Pulmonary;
Latent Tuberculosis;
Interferon-gamma Release Tests
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Cross-Sectional Studies;
Diagnosis, Differential;
Female;
Fluorodeoxyglucose F18/chemistry/*diagnostic use;
Follow-Up Studies;
Humans;
Interferon-gamma Release Tests;
Male;
Middle Aged;
Odds Ratio;
Positron-Emission Tomography;
Radiopharmaceuticals/chemistry/*diagnostic use;
Risk Factors;
Tomography, X-Ray Computed;
Tuberculin Test;
Tuberculosis/*diagnosis/radiography
- From:Journal of Korean Medical Science
2014;29(3):386-391
- CountryRepublic of Korea
- Language:English
-
Abstract:
The presence of radiographic lesions suggesting old healed tuberculosis (TB) is one of the strongest risk factors for the subsequent development of active TB. We elucidated the metabolic activity of radiographic lesions suggesting old healed TB using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). This cross-sectional study included 63 participants with radiographic lesions suggesting old healed TB and with available 18F-FDG PET/CT scans. The maximum standardized uptake value (SUVmax) measured in the lesions, the clinical characteristics, results of the tuberculin skin test (TST) and interferon-gamma release assay (IGRA) were analyzed. The SUVmax in old healed TB was 1.5 or higher among nine (14.3%) participants. Age (adjusted odds ratio [aOR], 1.23; 95% CI, 1.03-1.46), history of previous TB (aOR, 60.43; 95% CI, 1.71-2131.65), and extent of the lesions (aOR, 1.34; 95% CI, 1.02-1.75) were associated with higher SUVmax. The positive rates for the TST and IGRA were not different between groups with and without increased FDG uptake. Increased FDG uptake on 18F-FDG PET/CT was observed in a subset of patients with radiographic lesions suggesting old healed TB. Given that the factors associated with increased FDG uptake are known risk factors for TB development, the possibility exists that participants with old healed TB lesions with higher SUV on 18F-FDG PET/CT scans might be at higher risk for active TB.
