Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates.
10.3346/jkms.2014.29.3.456
- Author:
Dai Ho JANG
1
;
Cheol Hee YOON
;
Byeong Sun CHOI
;
Yoon Seok CHUNG
;
Hye Young KIM
;
Sung Gil CHI
;
Sung Soon KIM
Author Information
1. Division of AIDS, Korea National Institute of Health, Cheongwon, Korea. Sungskim@gmail.com
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Fusion Inhibitor;
Fusion Peptide;
Gp41 Polymorphism;
HIV-1 Envelope Glycoprotein;
T-20 Resistance Mutation
- MeSH:
Anti-HIV Agents/pharmacology;
Drug Resistance, Viral/*genetics;
HIV Envelope Protein gp41/*genetics/metabolism/pharmacology;
HIV Infections/virology;
HIV-1/*genetics/isolation & purification/*metabolism;
Humans;
Peptide Fragments/pharmacology;
*Polymorphism, Genetic;
Protein Structure, Tertiary/genetics;
Republic of Korea;
Virus Internalization
- From:Journal of Korean Medical Science
2014;29(3):456-459
- CountryRepublic of Korea
- Language:English
-
Abstract:
HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we analyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naive Koreans infected with HIV-1. This study of gp41 polymorphisms showed that insertions in the fourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusion peptide motif in Korean HIV-1 isolates compared with those from other countries. Minor T-20 resistance mutations such as L45M (1.2%), N126K (1.2%), and E137K (6.7%) were detected, but the critical T-20 resistance mutations were not detected in the gp41 HR1 and HR2 regions. In addition, the N42S mutation (12.9%) associated with T-20 hypersusceptibility was detected at a high frequency. These results may serve as useful data for studies considering T-20 for use in the development of a more effective anti-retroviral treatment in Korea.
