Meta-analysis of curative effects of micronutrient-assisted treatment for pulmonary tuberculosis
10.3760/cma.j.cn115682-20200328-02266
- VernacularTitle:微量营养素辅助治疗肺结核效果的Meta分析
- Author:
Li YU
1
;
Ming HOU
;
Yongxiu LIU
;
Ping LI
Author Information
1. 新疆维吾尔自治区人民医院护理部，乌鲁木齐 830000
- Keywords:
Micronutrients;
Pulmonary tuberculosis;
Vitamin;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2020;26(31):4335-4340
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical effect of micronutrient-assisted treatment for pulmonary tuberculosis.Methods:The databases including China National Knowledge Infrastructure (CNKI) , Wanfang Data, Chinese Biomedical Literature Database, PubMed, Web of Science and The Cochrane Library were searched by computer. The literature search time limit was from the establishment of the database to December 2019. Two researchers strictly followed the inclusion and exclusion criteria to evaluate the quality of the literatures, and then used RevMan 5.3 software to perform Meta-analysis.Results:A total of 12 randomized controlled trials (RCT) were included. Meta-analysis results showed that the effect of vitamin A on the hemoglobin level of patients was statistically significantly different from that of placebo [ MD=0.46, 95% CI (0.14, 0.77) , P=0.01]. Compared with placebo, the effect of zinc on hemoglobin level was statistically significantly different [ MD=0.32, 95% CI (0.04, 0.61) , P=0.03]. Compared with placebo, the effect of zinc on mortality was statistically significantly different [ RD=0.06, 95% CI (0.01, 0.11) , P=0.02]. Compared with the control group, there was no statistically significant difference in micronutrients in negative conversion rates of tuberculosis sputum smear ( P> 0.05) . Conclusions:The intake of micronutrients can increase the hemoglobin level and reduce the fatality rate of patients with pulmonary tuberculosis, but it has little influence on the negative conversion rate of tuberculosis sputum smear.
