Clinicopathological features analysis of 7 cases with sarcomatoid carcinoma of the pancreas
10.3760/cma.j.cn115667-20231117-00064
- VernacularTitle:胰腺肉瘤样癌7例临床病理特征分析
- Author:
Yijie MA
1
;
Huizhi ZHANG
;
Caide LU
;
Shengdong WU
;
Yiwen YANG
;
Yangke HU
;
Ke WANG
Author Information
1. 宁波大学附属李惠利医院肝胆外科，宁波 315048
- Keywords:
Pancreas;
Pathologic diagnosis;
Sarcomatoid carcinoma
- From:
Chinese Journal of Pancreatology
2024;24(5):338-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathologic features of sarcomatoid carcinoma of the pancreas.Methods:The clinicopathological data of 7 cases with sarcomatoid carcinoma of the pancreas admitted in the Affiliated Lihuili Hospital of Ningbo University from September 2013 to August 2021 were retrospectively analyzed, including clinical manifestations, laboratory examination, imaging examination, pathological examination of tissue specimens, surgical methods and adjuvant treatments. Expressions of mesenchymal markers and epithelial markers in tumor tissues were determined by immunohistochemical staining.Results:Among the 7 cases of sarcomatoid carcinoma of the pancreas, there were 4 male and 3 female. The patient age ranged from 51 to 88 years old, and the mean age was 69 years old. All the patients underwent CT examimation before surgery. 3 tumors were located in the head, 3 in the body and 1 in the tail of the pancreas. CT examination also showed that 4 tumors were cystic solid and 3 were cystic. Six patients underwent radical surgery and one underwent partial resection for biopsy. Microscopically, the tumor was predominantly composed of sarcomatoid spindle-shaped cells. Immunohistochemical staining showed that the tumor expressed both mesenchymal markers vimentin and epithelial marker CK7, CK19, CK(pan) and CAM5.2. The overall prognosis of the patients was poor, 4 cases died within 1 year after surgery, and the other 3 cases survived without recurrence.Conclusions:The clinical manifestations of sarcomatoid carcinoma of the pancreas were not typical, but the pathological and immunohistochemical features are obvious and the prognosis is poor.
