Meta-analysis on the comparison between plasma exchange and drugs in the treatment of hypertriglyceridemic pancreatitis
10.3760/cma.j.cn115667-20230914-00027
- VernacularTitle:血浆置换与药物治疗高三酰甘油血症性胰腺炎疗效比较的荟萃分析
- Author:
Xiaxia WENG
1
;
Junchao ZHANG
Author Information
1. 厦门市中医院消化内科，厦门 361000
- Keywords:
Pancreatitis;
Hypertriglyceridemia;
Plasma exchange;
Meta-analysis
- From:
Chinese Journal of Pancreatology
2024;24(4):270-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of plasma exchange and drugs in the treatment of hypertriglyceridemic pancreatitis (HTGP).Methods:Plasma exchange, exchange plasma,exchanges plasma, plasma or plasma exchanges, acute pancreatitis were used as keywords for research search, and the network English database such as PubMed, Embase, Cochrane Library were searched from database establishment to May 31, 2022. The prospective and retrospective cohort studies on plasma exchange and drugs in the treatment of HTGP were retrieved. The papers were screened and the quality was evaluated according to preset inclusion and exclusion criteria; and the important data were extracted. Meta-analysis was performed using RevMan5.3 software.Results:A total of 11 papers with 819 patients were included. Among them, 285 patients received plasma exchange, and 534 patients received drug treatment. The results of meta-analysis showed that plasma exchange decreased triglyceride faster than drug therapy ( OR=5.28, 95% CI 0.92-9.63, P<0.05), but plasma exchange was comparable to drug therapy on the incidence of pancreatic pseudocysts, pancreatic necrosis, acute renal failure, acute respiratory failure and shock, and mortality ( OR=0.54, 95% CI 0.23-1.29; OR=1.23, 95% CI 0.62-2.43; OR=0.85, 95% CI 0.25-2.91; OR=0.84, 95% CI 0.25-2.79; OR=0.64, 95% CI 0.31-1.34, OR=1.29, 95% CI 0.72-2.30; all P value >0.05), and patients with plasma exchange had longer hospital stays ( OR=2.09, 95% CI 0.10-4.08, P<0.05). Conclusions:Compared with drug therapy, plasma exchange can not reduce the mortality and complications of HTGP patients.
