Clinical comprehensive evaluation of single-pill combination of perindopril and amlodipine for treatment of hypertension
10.12173/j.issn.1005-0698.202405052
- VernacularTitle:培哚普利氨氯地平单片复方制剂治疗高血压的临床综合评价
- Author:
Juan WU
1
,
2
;
Xueyan TU
;
Ping LONG
;
Lu ZEGN
;
Lu WANG
;
Anhua WEI
Author Information
1. 华中科技大学同济医学院附属同济医院药学部(武汉 430033)
2. 泰康同济(武汉)医院药学部(武汉 430050)
- Keywords:
Perindopril and amlodipine;
Single-pill combination;
Hypertension;
Clinical application evaluation
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(11):1265-1275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of single-pill combination(SPC)of perindopril and amlodipine for the treatment of hypertension and provide reference for the selection and rational use in medical institutions.Methods A comprehensive clinical evaluation index system was established based on literature research and expert demonstration.Therefore,the safety,effectiveness,economy,innovation,suitability and accessibility of drugs were analyzed qualitatively and quantitatively.Results A total of 12 studies reported the outcome of perindopril and amlodipine SPC,including efficacy and safety.Perindopril amlodipine SPC was safe,and there was no significant difference in the incidence of adverse events during treatment compared with monotherapy,monotherapy combination or other antihypertensive SPC.In terms of effectiveness,perindopril and amlodipine SPC had clear antihypertensive effect,which could significantly reduce systolic blood pressure,diastolic blood pressure,pulse pressure difference and heart rate,and the blood pressure compliance rate of perindopril and amlodipine SPC was better than that of amlodipine or perindopril monotherapy group.Compared with other depressurized SPCs,it showed better or non-inferior effect.Perindopril amlodipine SPC,as a patented drug,has good innovation,high patient compliance,and has been included in China's medical insurance catalog,but the current medical institutions have a low supply rate,and drug prices and affordability are still at a relatively high level.Conclusion Perindopril amlodipine SPC has significant advantages in safety,effectiveness,suitability and innovation,but its economy and accessibility still need to be improved.
