Study of the etoricoxib combined with Bitong decoction formula on the clinical effect and serum level in patients with knee osteoarthritis
10.12173/j.issn.1005-0698.202409070
- VernacularTitle:依托考昔联合痹痛汤方对膝骨关节炎患者临床疗效及血清相关水平影响研究
- Author:
Yezhou LI
1
;
Chengjian TANG
;
Pei CHEN
;
Qing CHEN
Author Information
1. 湖南中医药大学第一附属医院骨科(长沙 410021)
- Keywords:
Knee osteoarthritis;
Etoricoxib;
Bitong decoction formula;
Efficacy;
Inflammatory factors;
Oxidative stress
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(11):1201-1208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of etoricoxib combined with Bitong decoction formula on the clinical efficacy and serum level of patients with knee osteoarthritis.Methods Retrospective analysis was used to collect patients with knee osteoarthritis admitted to our hospital from August 2022 to August 2023.According to the medication method,they were divided into the combined group and the control group.The control group was given etoricoxib tablets,and the combination group was given a combination of Bitong decoction formula on the basis of the control group.Both groups were treated for one month.The efficacy after treatment,Traditional Chinese Medicine(TCM)syndrome score,the knee joint function[osteoarthritis index(WOMAC),Lequesne score],inflammatory indicators[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),matrix metalloproteinase-3(MMP-3),tissue inhibitor of metalloproteinase-1(TIMP-1)],oxidative stress indicators[total antioxidant capacity(TAOC),lipid peroxidation(LPO),nitric oxide(NO)]before and after treatment and safety of the two groups were compared.Results A total of 162 patients were included,with 81 in each group.The overall efficacy and total effective rate of the combined group were higher than those of the control group(P＜0.05).After treatment,TCM syndrome score,WOMAC,Lequesne score,IL-1 β,TNF-α,MMP-3,TIMP-1,LPO and NO levels in two groups were decreased compared with before treatment,while TAOC increased compared with before treatment(P＜0.05),and all the above indexes in the combination group were better than those in the control group(P＜0.05).The safety of the two groups was comparable(P＞0.05).Conclusion The efficacy of etoricoxib combined with Bitong decoction formula in knee osteoarthritis is better than that of single western medicine,which can alleviate symptoms and improve knee joint function,as well as reduce inflammation and oxidative stress,and has high safety.
