Efficacy of edaravone dexborneol combined with alteplase in the treatment of acute ischemic stroke:a randomized controlled trial
10.12173/j.issn.1005-0698.202404060
- VernacularTitle:依达拉奉右莰醇联合阿替普酶治疗急性缺血性脑卒中疗效的随机对照试验
- Author:
Weijie WU
1
;
Zihui SUN
;
Liang'e XU
;
He HUANG
;
Xuerong HUANG
Author Information
1. 温州医科大学附属第三医院神经内科(浙江温州 325200)
- Keywords:
Edaravone dexborneol;
Alteplase;
Acute ischemic stroke;
Intravenous thrombolysis;
Efficacy
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(9):978-985
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of edaravone dexborneol combined with intravenous thrombolysis with alteplase,in the treatment of patients with acute ischemic stroke(AIS).Methods The patients with AIS undergoing intravenous thrombolysis with alteplase between January 7,2021 and December 31,2022 were enrolled and randomly divided into observation group and control group.The control group was treated with standard treatment according to the AIS guidelines,and the observation group was treated with edaravone dexborneol injection within 48 hours from thrombolysis to the onset of the disease on the basis of the treatment in the control group.7-day post-thrombolysis National Institutes of Health stroke scale(NIHSS),discharged NIHSS,difference between 7-day post-thrombolysis NIHSS and pre-thrombolysis NIHSS,and 3-month all-cause mortality and 3-month poor prognosis ratio were compared between the two groups.Results A total of 232 patients with AIS were randomly allocated to the observation group(n=1 16)and the control group(n=1 16).The differences between the two groups were not statistically significant for 7-day post-thrombolysis NIHSS and difference between 7-day post-thrombolysis NIHSS and pre-thrombolysis NIHSS(P＞0.05),and there were statistical differences in distribution of the discharged NIHSS score between the observation group and control group[2.0(0,3.0)vs.2.0(1.0,5.0),P＜0.05].The 3-month poor prognosis ratio was significantly lower in the observation group than in the control group(12.1％vs.28.4％;OR=0.252,95％CI 0.105 to 0.602,P=0.002).Conclusion Edaravone dexborneol enhances the efficacy of AIS undergoing intravenous thrombolysis with alteplase and improves the 3-month outcome of patients.
