Causal associations between statins and type 1 or type 2 diabetes:a two-sample mendelian randomization study
10.12173/j.issn.1005-0698.202403050
- VernacularTitle:他汀类药物与1型或2型糖尿病的因果关系:一项两样本孟德尔随机化研究
- Author:
Liyan WENG
1
;
Jinyan WENG
;
Jing XU
Author Information
1. 丽水市中心医院药学部(浙江丽水 323000)
- Keywords:
Statins;
Type 1 diabetes;
Type 2 diabetes;
Causality;
Mendelian randomization;
Genome-wide association study
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(8):869-876
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causal relationship between statins and type 1 or type 2 diabetes mellitus by using Mendelian randomization(MR).Methods Based on the collected data of genome-wide association studies(GWAS),single nucleotide polymorphism(SNP),which were independent of each other and highly correlated with statins and diabetes mellitus,were selected as tool variables.MR-Egger regression,weighted median,inverse variance weighting(IVW),simple mode and weighted mode were used for two-sample MR analyses to evaluate the causal relationship between statins and type 1 or type 2 diabetes respectively,and heterogeneity tests,multiplicity analyses,and sensitivity analysis to evaluate the reliability of the study.Results A total of 78 SNPs independently associated with statins were included as tool variables in this study at the genome-wide significance level(P＜5×10-8).The results of IVW analysis showed that statins were causally associated with an increased risk of type 1 diabetes mellitus(OR=1.524,95％CI 1.077 to 2.157,P=0.017),and there was also a causal relationship between statins and the increased risk of type 2 diabetes(OR=1.261,95％CI 1.165 to 1.366,P＜0.001).The results were not affected by multiplicity and heterogeneity,and the reliability of the results was verified by sensitivity analysis.Conclusion Statins may be a risk factor for increasing the risk of type 1 or type 2 diabetes.However,further studies with larger sample sizes of GWAS data are still needed to verify the causal association.
