Clinical study on effect of Qili Qiangxin capsules on the prognosis in patients with ST-segment elevation myocardial
10.12173/j.issn.1005-0698.202404001
- VernacularTitle:芪苈强心胶囊对ST段抬高型心肌梗死预后影响的临床研究
- Author:
Hailong ZHU
1
;
Weigang XIAO
;
Shaofei ZHANG
Author Information
1. 河北医科大学附属平安医院(石家庄平安医院)中医科(石家庄 050026)
- Keywords:
Qili Qiangxin capsules;
ST elevation myocardial infarction;
Major adverse cardiovascular and cerebrovascular events;
Prognosis
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(6):612-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic impact of Qili Qiangxin capsules(QLQX)in patients with ST-segment elevation myocardial infarction(STEMI).Methods Retrospective collecting the clinical data of STEMI patients treated at PingAn Hospital affiliated to Hebei Medical University from January 2020 to January 2022,divided into QLQX group and non-QLQX group according to treatment plan.Follow-up patients for 1 year,with the main endpoint being major adverse cardiovascular and cerebrovascular events(MACCEs)at 30 d and 1 year;The secondary endpoints were cardiogenic death,myocardial reinfarction,emergency coronary revascularization,stroke,and major bleeding at 30 d and 1 year,as well as severe STEMI complications(30 d),re-admission due to heart failure(1 year),and all-cause mortality(1 year).Results A total of 210 STEMI patients were included(125 in the QLQX group and 85 in the non QLQX group).Univariate or Kaplan Meier analysis showed that the MACCE,cardiogenic death,malignant arrhythmia at 30 d,myocardial reinfarction,re-admission due to heart failure,and all-cause mortality rates in the QLQX group were significantly lower than those in the non QLQX group at 30 d and 1 year(P＜0.05),while there were no significant differences in the incidence of other observed endpoint events between the two groups(P＞0.05).In addition,QLQX may be a protective factor for MACCEs in STEMI patients(30 d:HR=0.157,95％CI 0.032 to 0.756,P=0.021;1 year:HR=0.208,95％CI 0.087 to 0.497,P=0.014).Conclusion QLQX adjuvant therapy may improve MACCEs in STEMI patients.
