Application of colostrum oral immunotherapy in feeding of very low birth weight infants
10.3760/cma.j.cn115682-20191021-03792
- VernacularTitle:初乳口腔免疫疗法在极低出生体重儿喂养中的应用
- Author:
Meiqin XIANG
1
;
Xiping ZHAO
;
Weitong LI
Author Information
1. 济宁医学院附属医院新生儿监护病房，济宁 272100
- Keywords:
Infant, newborn;
Very low birth weight infants;
Feeding intolerance;
Colostrum oral immunotherapy;
Intestinal probiotics;
Growth and development
- From:
Chinese Journal of Modern Nursing
2020;26(27):3803-3807
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application effects of dual probiotic preparation and colostrum oral immunotherapy on improving feeding intolerance in very low birth weight infants.Methods:A systematic sampling method was used to select 173 very low birth weight infants who were admitted to the Neonatal Intensive Care Unit (NICU) from December 2017 to December 2018. According to the random number table method, they were divided into in group A ( n=56) , group B ( n=59) and group C ( n=58) . Group A was given routine nursing, parenteral nutrition and enteral nutrition and minimal breast feeding. Group B was given dual probiotic preparation on the basis of routine nursing. Group C was given colostrum oral immunotherapy on the basis of routine nursing. After 7 days of intervention, the improvement of feeding intolerance was observed, and the feeding intolerance rates were compared among the three groups after 3 d, 5 d and 7 d of intervention. Intestinal flora, incidence of complications, length of NICU stay and speed of birth weight recovery were compared. Results:The intake of milk in group B and group C were higher than those in group A, and the retention milk volume, retention times and duration of abdominal distension were all lower than those in group A, while retention times and duration of abdominal distension in group C were shorter than those of group B, and the differences were statistically significant ( P<0.05) . On the 3rd, 5th and 7th day of intervention, the feeding intolerance rates of the three groups continued to decrease. The feeding intolerance rates of group B and C were lower than those of group A, and the feeding intolerance rate of group C was lower than that of group B on the 3rd day of intervention , and the differences were statistically significant ( P<0.05) . The number of Enterococcus faecium, the number of Bacillus subtilis and the ratio of the logarithmic number of bifidobacteria to the logarithmic number of Escherichia coli (B/E value) in groups B and C were all higher than those in group A, and the incidences of sepsis and necrotizing enterocolitis in group B and group C were lower than those in group A, and the differences were statistically significant ( P<0.05) . The length of stay in NICU was ranked from long to short as Group A, Group B, and group C, and the speed of birth weight recovery was ranked from slow to fast as group A, Group B, and group C, and the differences were statistically significant ( P<0.05) . Conclusions:Colostrum oral immunotherapy can improve the feeding intolerance of very low birth weight infants, reduce complications related to premature delivery, promote the growth and development of neonates and shorten the length of stay in NICU. The clinical effect is slightly better than that of probiotics.
