Drug use evaluation of bemiparin sodium injection based on weighted TOPSIS method
10.12173/j.issn.1005-0698.202306021
- VernacularTitle:基于加权TOPSIS法的贝米肝素钠注射液药物利用评价
- Author:
Lulu TIAN
1
;
Meijuan LI
;
Deqiu ZHU
;
Huiya CAI
;
Jinhua ZHANG
Author Information
1. 同济大学附属同济医院药剂科(上海 200065)
- Keywords:
Bemiparin sodium injection;
Weighted TOPSIS method;
Drug use evaluation
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(5):481-488
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the drug use evaluation(DUE)criteria for bemiparin sodium injection,and evaluate the use of bemiparin sodium injection by weight technique for order prefer by similarity to ideal solution(TOPSIS),and to provide reference for improving the rational use of bemiparin sodium injection.Methods Based on the instructions of bemiparin sodium injection,and referring to relevant guidelines and literatures,the DUE criteria of bemiparin sodium injection was established by expert consultation.The weighted TOPSIS method was used to evaluate the rationality medication in the cases of inpatients who use bemiparin sodium injection from June to July 2021 in the Tongji Hospital of Tongji University.Results In the established DUE criteria of bemiparin sodium injection,the top two relative weight coefficients of ten secondary indicators were contraindications and adverse reaction disposal,and the bottom two were administration methods and indications.A total of 100 medical records were including.There was not a case close to the optimal regimen(Ci≥0.8)(reasonable);Ci was between 0.6 and 0.8(basically reasonable)in 83 cases(83.00％);and Ci＜0.6(unreasonable)in 17 cases(17.00％).The unreasonable uses of bemiparin sodium injection mainly appeared in off-lable uses of indications and the dosing method,a potential drug-drug interaction,inappropriate dosage,and violation of drug contraindications.Conclusion The drug use evaluation method of bemiparin sodium injection based on weighted TOPSIS method can synthesize multiple evaluation indexes,and the evaluation results are objective and reliable.The results showed that most clinical application of bemiparin sodium injection in this hospital was basically reasonable,but to provide basis for rational clinical drug use and to ensure patients'medication safety,it is necessary to accelerate the off-label evidence-based evaluation process and strengthen the management of rational drug use.
