Drug use evaluation of bivalirudin for injection based on weighted TOPSIS method
10.12173/j.issn.1005-0698.202306020
- VernacularTitle:基于加权TOPSIS法的注射用比伐芦定药物利用评价
- Author:
Ruijuan LI
1
,
2
;
Meijuan LI
;
Xiaolong MI
;
Weihong CHEN
;
Zhihong LI
;
Xiaomin WANG
;
Jinhua ZHANG
Author Information
1. 山西白求恩医院/山西医学科学院同济山西医院/山西医科大学第三医院药学部(太原 030032)
2. 华中科技大学同济医学院附属同济医院(武汉 430030)
- Keywords:
Bivalirudin;
Drug use evaluation;
Weighted TOPSIS method;
Rational drug use
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(4):361-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the drug use evaluation(DUE)standard of bivalirudin for injection,and to evaluate the use of the drug by weighted TOPSIS method,so as to provide a reference for rational use of bivalirudin.Methods Based on the package insert,clinical guidelines and consensus of experts of bivalirudin,the DUE standards were developed,and the weighted TOPSIS method was used to evaluate the rationality of the discharge medical records of Shanxi Bethune Hospital from January 1st to June 30th in 2022.Results Incorporating 108 medical records involving the use of bivalirudin for injection,88 cases(81.48％)exhibited a high degree of adherence(Ci≥0.8)between the prescribed drug regimens and the optimal recommendations,which is considered reasonable.Additionally,19 cases(17.59％)fell within the range of 0.6＜Ci＜0.8,indicating a generally reasonable adherence.Only one case(0.93％)had a Ci＜0.6,suggesting an unreasonable level of adherence.The irrational situations about various evaluation indicators in the DUE were mainly manifested in the inappropriate dosages of administration(12.04％),inappropriate disposal of adverse reactions(11.11％),using medicine with contraindications(3.70％),using medicine without indication(1.85％),inappropriate monitoring of adverse reactions(0.93％),etc.Conclusion The established DUE standards for bivalirudin are intuitive and comprehensive,and the evaluation results show that there are some unreasonable situations in the use of bivalirudin in the hospital,and it is necessary to standardize the use of bivalirudin in terms of dosages,disposal of adverse reactions,indication and contraindication.
