miR-135b:An emerging player in cardio-cerebrovascular diseases
10.1016/j.jpha.2024.100997
- Author:
Shao YINGCHUN
1
;
Xu JIAZHEN
;
Chen WUJUN
;
Hao MINGLU
;
Liu XINLIN
;
Zhang RENSHUAI
;
Wang YANHONG
;
Dong YINYING
Author Information
1. The Affiliated Hospital of Qingdao University,Qingdao University,Qingdao Cancer Institute,Qingdao,266071,China
- Keywords:
miR-135b;
Myocardial injury;
Brain injury;
Cardiovascular diseases;
Cerebrovascular diseases
- From:
Journal of Pharmaceutical Analysis
2024;14(10):1407-1417
- CountryChina
- Language:Chinese
-
Abstract:
miR-135 is a highly conserved miRNA in mammals and includes miR-135a and miR-135b.Recent studies have shown that miR-135b is a key regulatory factor in cardio-cerebrovascular diseases.It is involved in regulating the pathological process of myocardial infarction,myocardial ischemia/reperfusion injury,cardiac hypertrophy,atrial fibrillation,diabetic cardiomyopathy,atherosclerosis,pulmonary hyperten-sion,cerebral ischemia/reperfusion injury,Parkinson's disease,and Alzheimer's disease.Obviously,miR-135b is an emerging player in cardio-cerebrovascular diseases and is expected to be an important target for the treatment of cardio-cerebrovascular diseases.However,the crucial role of miR-135b in cardio-cerebrovascular diseases and its underlying mechanism of action has not been reviewed.Therefore,in this review,we aimed to comprehensively summarize the role of miR-135b and the signaling pathway mediated by miR-135b in cardio-cerebrovascular diseases.Drugs targeting miR-135b for the treatment of diseases and related patents,highlighting the importance of this target and its utility as a therapeutic target for cardio-cerebrovascular diseases,have been discussed.
