β-elemene promotes miR-127-3p maturation,induces NSCLCs autophagy,and enhances macrophage M1 polarization through exosomal communication
10.1016/j.jpha.2024.03.002
- Author:
Wu XIAHUI
1
,
2
;
Wu JIE
;
Dai TINGTING
;
Wang QIANGCHENG
;
Cai SHENGJIE
;
Wei XUEHAN
;
Chen JING
;
Jiang ZIYU
Author Information
1. Department of Oncology,Lianyungang Integrated Traditional Chinese and Western Medicine Clinical College,Nanjing University of Chinese Medicine,Nanjing,222002,China
2. Department of Oncology,The First People's Hospital of Lianyungang,Lianyungang,Jiangsu,222002,China
- Keywords:
β-elemene;
miR-127-3p;
NSCLC;
Akt/mTOR/p70S6K;
MAPK4
- From:
Journal of Pharmaceutical Analysis
2024;14(9):1347-1360
- CountryChina
- Language:Chinese
-
Abstract:
β-elemene has been observed to exert inhibitory effects on a multitude of tumors,primarily through multiple pathways such as the inhibition of cancer cell proliferation and the induction of apoptosis.The present study is designed to elucidate the role and underlying mechanisms of β-elemene in the thera-peutic intervention of non-small cell lung cancer(NSCLC).Both in vitro and in vivo experimental models corroborate the inhibitory potency of β-elemene on NSCLCs.Our findings indicate that β-elemene fa-cilitates the maturation of miR-127-3p by inhibiting CBX8.Functioning as an upstream regulator of MAPK4,miR-127-3p deactivates the Akt/mTOR/p70S6K pathway by targeting MAPK4,thereby inducing autophagy in NSCLCs.Additionally,β-elemene augments the packaging of miR-127-3p into exosomes via SYNCRIP.Exosomal miR-127-3p further stimulates M1 polarization of macrophages by suppressing ZC3H4.Taken together,the detailed understanding of the mechanisms through which β-elemene in-duces autophagy in NSCLCs and facilitates M1 polarization of macrophages provides compelling scientific evidence supporting its potential utility in NSCLC treatment.
