Nursing care for immune-related skin toxicity caused by programmed cell death protein 1 inhibitor
10.3760/cma.j.cn115682-20191227-04801
- VernacularTitle:程序性死亡蛋白1抑制剂引起免疫相关性皮肤毒性的护理
- Author:
Yan WANG
1
;
Ruixian HE
;
Minfeng ZHAI
;
Weicai SU
Author Information
1. 国家癌症中心/中国医学科学院北京协和医学院肿瘤医院内科，北京 100021
- Keywords:
Nursing care;
Programmed cell death protein 1 inhibitor;
Immune-related skin toxicity reaction
- From:
Chinese Journal of Modern Nursing
2020;26(25):3526-3529
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the adverse effects of skin toxicity after the administration of programmed cell death protein 1 (PD-1) inhibitor, summarize the nursing measures, and provide a basis for taking corresponding management measures.Methods:Totally 94 patients who were treated with PD-1 inhibitor in Cancer Hospital of Chinese Academy of Medical Sciences between February and October 2019 were selected by convenient sampling, among whom 37 cases (39.4%) with skin toxicity reaction were included as the research subjects. Their skin toxicity was observed and assessed. Meanwhile, health education, psychological counseling and nursing care for skin toxicity reaction were provided to them.Results:Of the 37 patients, 34 (91.9%) had G1 skin toxicity and were not treated with drugs. After the rash subsided, they were treated according to the original plan. 2 (5.4%) had G2 skin toxicity, whose rash subsided after drug treatment, with scattered pigmentation. They were treated according to the original plan. 1 (2.7%) had G4 skin toxicity. The medical staff from the Dermatology Department and the Infection Department were consulted. The body temperature was normal, and the skin and mucous membranes were ruptured, crusted and detached. The patient was discharged after the condition was improved.Conclusions:After receiving PD-1 inhibitor immunotherapy, patients may have different degrees of immune-related skin toxicity reactions, which requires clinicians and nurses to carry out standardized treatment and care to improve their quality of life.
