Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
10.1016/j.jpha.2023.12.001
- Author:
Gao TING
1
;
Li YIXUAN
;
Wang XIAOYU
;
Ren FAZHENG
Author Information
1. Department of Nutrition and Health,College of Veterinary Medicine,China Agricultural University,Beijing,100083,China
- Keywords:
Alginate oligosaccharide;
Skin aging;
Butyrate;
HIF-1α;
Mitophagy
- From:
Journal of Pharmaceutical Analysis
2024;14(5):678-692
- CountryChina
- Language:Chinese
-
Abstract:
The"gut-skin"axis has been proved and is considered as a novel therapy for the prevention of skin aging.The antioxidant efficacy of oligomannonic acid(MAOS)makes it an intriguing target for use to improve skin aging.The present study further explored whereby MAOS-mediated gut-skin axis balance prevented skin aging in mice.The data indicated the skin aging phenotypes,oxidative stress,skin mitochondrial dysfunction,and intestinal dysbiosis(especially the butyrate and HIF-1 α levels decreased)in aging mice.Similarly,fecal microbiota transplantation(FMT)from aging mice rebuild the aging-like phenotypes.Further,we demonstrated MAOS-mediated colonic butyrate-HIF-1α axis homeostasis promoted the entry of butyrate into the skin,upregulated mitophagy level and ultimately improving skin aging via HDAC3/PHD/HIF-1α/mitophagy loop in skin of mice.Overall,our study offered a better insights of the effectiveness of alginate oligosaccharides(AOS),promised to become a personalized targeted therapeutic agents,on gut-skin axis disorder inducing skin aging.
