Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model
10.1016/j.jpha.2023.12.004
- Author:
Qian YUANYUAN
1
,
2
,
3
;
Wang XITING
;
Cai LULU
;
Han JIANGXUE
;
Huang ZHU
;
Lou YAHUI
;
Zhang BINGYUE
;
Wang YANJIE
;
Sun XIAONING
;
Zhang YAN
;
Zhu AISONG
Author Information
1. Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome,Zhejiang Chinese Medical University,Hangzhou,310000,China
2. Zhejiang Engineering Research Center for"Preventive Treatment"Smart Health of Traditional Chinese Medicine,Zhejiang Chinese Medical University,Hangzhou,310000,China
3. College of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou,310000,China
- Keywords:
Chinese herbal medicine formulas;
Precision medicine;
Mathematical modeling;
Systems biology;
Coronary heart disease;
Depression;
Ischemia-reperfusion;
Inflammation
- From:
Journal of Pharmaceutical Analysis
2024;14(4):585-600
- CountryChina
- Language:Chinese
-
Abstract:
Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex diseases.To characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(DeepTCM).DeepTCM has gone through multilevel model cali-bration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(TCM).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the formulas.Furthermore,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease interactions.Finally,we experimentally confirmed the thera-peutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and mice.This novel multiscale model opened up a new avenue to combine"disease syndrome"and"macro micro"system modeling to facilitate translational research in CHM formulas.
