An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke
10.1016/j.jpha.2023.11.010
- Author:
Wang JUNFENG
1
,
2
;
Liu QIBING
;
Li YINGBO
;
Pang YI
Author Information
1. Department of Chemistry,The University of Akron,Akron,OH 44325,USA
2. Gordon Center for Medical Imaging,Department of Radiology,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,USA
- Keywords:
Near-infrared;
Molecular imaging;
Thrombus;
Stroke
- From:
Journal of Pharmaceutical Analysis
2024;14(4):578-584
- CountryChina
- Language:Chinese
-
Abstract:
A two-photon near infrared(NIR)fluorescence turn-on sensor with high selectivity and sensitivity for Zn2+detection has been developed.This sensor exhibits a large Stokes'shift(-300 nm)and can be excited from 900 to 1000 nm,with an emission wavelength of-785 nm,making it ideal for imaging in biological tissues.The sensor's high selectivity for Zn2+over other structurally similar cations,such as Cd2+,makes it a promising tool for monitoring zinc ion levels in biological systems.Given the high concentration of zinc in thrombi,this sensor could provide a useful tool for in vivo thrombus imaging.
