Risperidone-Induced Mania in Psychoses.
- Author:
Dong Seon CHUNG
1
;
Sang Woo HAN
;
Sun Ho HAN
Author Information
1. Department of Neuropsychiatry, College of Medicine, Soonchunhyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Risperidone;
Mania;
5-HT2 receptor
- MeSH:
Antipsychotic Agents;
Bipolar Disorder*;
Humans;
Mood Disorders;
Psychotic Disorders*;
Receptors, Serotonin;
Risperidone;
Schizophrenia;
Serotonin
- From:Journal of Korean Neuropsychiatric Association
1998;37(2):394-399
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Risperidone is one of a new class of atypical antipsychotic drug that combines potent dopamine(D2) and serotonin(5-HT2) receptor antagonist properties. In the last few years, there have been several report of risperidone-induced manic symptoms during treatment of schizoaffective disorder or schizophrenia. We report three cases of mania developed in two schizophrenia patients and one amphetamine-induced psychotic disorder which appear to have been precipitated by rispendone. This inducing effect might be attributed to its ability to block postsynaptic 5-HT2 receptors, a property that distinguishes it self from other antipsychotic agents. The blocking of serotonin receptors by risperidone may create a perceived depletion of serotonin similar to that seen in affective disorder and lead to mania. Therefore, we should be cautions in the treatment of psychotic disorder with risperidone.
