Relationship between quantitative parameters of dual-energy CT and lymph node metastasis in patients with early non-small cell lung cancer
10.3760/cma.j.cn115455-20230626-00692
- VernacularTitle:双能量CT定量参数与早期非小细胞肺癌患者纵隔淋巴结转移的关系研究
- Author:
Jianxun FENG
1
;
Jun YAO
;
Chun CHANG
Author Information
1. 东台市人民医院呼吸与危重症医学科，东台 224200
- Keywords:
Carcinoma, non-small-cell lung;
Mediastinum;
Lymphatic metastasis;
Dual-energy CT;
Quantitative parameter
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(12):1135-1139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between quantitative parameters of dual-energy CT and lymph node metastasis in patients with early non-small cell lung cancer (NSCLC).Methods:A total of 120 patients with NSCLC (NSCLC group) admitted to Dongtai People′s Hospital from April 2021 to April 2023 were selected retrospectively, and another 120 patients with pneumonia nodules (pneumonia nodules group) during the same period were selected. All patients were given dual-energy CT examination. CT quantitative parameters including standardized iodine concentration in venous phase (NICVP), standardized iodine concentration in arterial phase (NICAP) and standardized iodine concentration (ICD) were compared between the two groups. Patients in the NSCLC group were divided into the metastatic group (40 cases) and the non-metastatic group (80 cases) according to the presence or non-presence of lymph node metastasis. Quantitative CT parameters of the two groups were compared, CT signs of the two groups were compared. The receiver operating characteristics (ROC) curve was drawn, and the diagnostic efficacy of quantitative CT parameters on lymph node metastasis in NSCLC patients was analyzed.Results:The NICVP, NICAP and ICD in the NSCLC group were higher than those in the pneumonia nodules group: 0.23 ± 0.04 vs. 0.17 ± 0.02, 0.58 ± 0.16 vs. 0.42 ± 0.10, 0.36 ± 0.08 vs. 0.24 ± 0.03, there were statistical differences ( P<0.01). The NICVP, NICAP and ICD in the metastatic group were higher than those in non-metastatic group: 0.25 ± 0.03 vs. 0.18 ± 0.03, 0.61 ± 0.24 vs. 0.51 ± 0.13, 0.37 ± 0.10 vs. 0.26 ± 0.04, there were statistical differences ( P<0.01). The pleural depression sign, burr sign, mediastinum lymph node short diameter between metastasis group and non-metastatic group had statistical differences ( P<0.05). The results of ROC curve analysis showed that the area under the curve of the combined detection of NICVP, NICAP and ICD for the diagnosis of lymph node metastasis in NSCLC patients was 0.852 (95% CI 0.822 - 0.957), the sensitivity was 94.96%, the specificity was 90.12%, and were higher than those of single detection ( P<0.05). Conclusions:Quantitative dual-energy CT detection can improve the diagnostic sensitivity and specificity of lymph node metastasis in NSCLC patients, and provide CT signs to assist clinical diagnosis of lymph node metastasis.
