Logistic regression model study of thromboelastogram parameters on cognitive impairment in patients with recurrent ischemic stroke
10.3760/cma.j.cn115455-20230805-00085
- VernacularTitle:血栓弹力图参数对复发性缺血性脑卒中患者认知障碍的Logistic回归模型研究
- Author:
Leilei FU
1
;
Weiwei CHEN
;
Liuyan WANG
Author Information
1. 义乌市中心医院输血科，义乌 322000
- Keywords:
Thrombelastography;
Brain infarction;
Cognition disorders;
Nomograms
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(10):949-953
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic value of thromboelastogram (TEG) parameters for cognitive impairment in patients with recurrent ischemic stroke (RIS), and construct a nomograph model.Methods:The clinical data of 75 patients with RIS and treated in the Yiwu Central Hospital from June 2020 to June 2022 were retrospectively summarized. Multivariate Logistic regression model was used to screen the risk factors of cognitive impairment in RIS patients. R software was used to establish a nomogram model, and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of TEG index and nomogram on cognitive impairment in RIS patients.Results:The results of multivariate Logistic regression analysis showed that National Institutes of Health Stroke Scale (NIHSS) score on admission, stroke interval, change in clotting time 48 h after admission and 48 h before discharge (ΔR) and change in maximum clot intensity (ΔMA) were the risk factors for cognitive impairment 3 months after RIS ( P<0.05). Age, ΔR and ΔMA were the risk factors for cognitive impairment 12 months after the onset of RIS ( P<0.05). ROC curve analysis showed that the area under the curve (AUC) predicted by the nomogram for cognitive impairment 3 and 12 months after the onset of RIS was higher than that of the patients with ΔR and ΔMA ( P<0.01). Conclusions:Detection of TEG parameters, especially ΔR and ΔMA, establishment of nomogram model have good practical value for guiding clinical rapid identification of high-risk patients with cognitive impairment.
