Serum levels of myeloperoxidase, interleukin-1β, transforming growth factor-β1 and their correlation with uric acid in patients with gout
10.3760/cma.j.cn115455-20230512-00508
- VernacularTitle:痛风患者血清髓过氧化物酶、白细胞介素-1β、转化生长因子-β1水平检测及其与尿酸水平相关性研究
- Author:
Tingwei LI
1
;
Danhua LAO
;
Qiuju LIU
;
Yaqing MO
Author Information
1. 广西医科大学第十附属医院（钦州市第一人民医院）全科医学科，钦州 535000
- Keywords:
Hyperuricemia;
Uric acid;
Gout;
Myeloperoxidase;
Interleukin-1β;
Transforming growth factor-β1
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(10):936-940
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serum levels of myeloperoxidase (MPO), interleukin-1β (IL-1β) and transforming growth factor-β1 (TGF-β1) in patients with hyperuric acid gout, and to analyze their correlation and interaction with uric acid.Methods:A total of 120 male patients with hyperuricemia (HUA) diagnosed and treated in the Tenth Affiliated Hospital of Guangxi Medical University (Qinzhou First People′s Hospital) from December 2019 to December 2022 were selected as the study objects, including 55 patients with gout as the observation group and 65 patients without gout as the control group. Serum levels of uric acid, MPO, IL-1β and TGF-β1 were compared between the two groups, Logistic regression was used to analyze the risk factors of HUA with gout, and Pearson test was used to analyze the correlation between serum uric acid level and MPO, IL-1β and TGF-β1 levels, the interactions were calculated by the likelihood ratio test.Results:The levels of serum uric acid, MPO, IL-1β and TGF-β1 in the observation group were higher than those in the control group: (559.63 ± 70.62) μmol/L vs. (448.24 ± 50.49) μmol/L, (0.37 ± 0.10) mmol/L vs. (0.29 ± 0.07) mmol/L, (49.83 ± 5.03) ng/L vs. (42.15 ± 4.77) ng/L, (34.15 ± 6.82) μg/L vs. (28.97 ± 5.14) μg/L, there were statistical differences ( P<0.05). The results of Logistic regression showed that serum uric acid, MPO, IL-1β and TGF-β1 levels were risk factors for hyperuric acid gout ( P<0.05). The results of Pearson test showed that serum uric acid were positively correlated with the levels of MPO, IL-1β and TGF-β1( r = 0.760, 0.775, 0.759, P<0.05), and there was interaction in the pathogenesis of hyperuric acid gout ( P<0.05). Conclusions:The high levels of MPO, IL-1β and TGF-β1 at the same time can increase the risk of hyperuric acid gout.
