The expression levels of thyroid transcription factor-1 and galectin-3 in pleural fluid sediment embedded tissues of lung adenocarcinoma patients and their clinical significance
10.3760/cma.j.cn115455-20230524-00543
- VernacularTitle:肺腺癌患者胸腔积液沉渣包埋组织中甲状腺转录因子-1、半乳糖苷酶类-3表达水平及其临床意义
- Author:
Jing LU
1
;
Linyu ZHANG
;
Shijie DENG
Author Information
1. 安庆市第一人民医院病理科，安庆 246000
- Keywords:
Adenocarcinoma of lung;
Hydrothorax;
Sediment embeds tissue;
Thyroid transcription factor-1;
Galactin 3
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(10):923-926
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression levels and clinical significance of thyroid transcription factor-1(TTF-1) and galectin-3 in pleural fluid sediment embedded tissues of lung adenocarcinoma patients.Methods:A study was conducted on the clinical data of 82 lung cancer patients who received treatment at the First People′s Hospital of Anqing City from March 2020 to December 2022. According to the type of lung adenocarcinoma, they were divided into metastatic lung adenocarcinoma group (16 cases) and primary lung adenocarcinoma group (66 cases). The expression of levels TTF-1 and galectin-3 were compared between the two groups. Immunohistochemical method was used to detect the expression levels of TTF-1 and galectin-3 in pleural fluid sediment embedded tissues and their clinical significance was analyzed.Results:The positive rate of TTF-1 in primary lung adenocarcinoma group was higher than that in metastatic lung adenocarcinoma group: 77.27%(51/66) vs. 2/16, there was statistical difference ( χ2 = 23.64, P<0.01). The positive rate of galectin-3 in primary adenocarcinoma group was lower than that in metastatic adenocarcinoma group: 31.82%(21/66) vs. 13/16, there was statistical difference ( χ2 = 12.96, P<0.01). Galectin-3 and TTF-1 positive expressions were not correlated with the degree of tissue differentiation, lymph node metastasis and clinical stage of lung adenocarcinoma ( P>0.05). Conclusions:The expression level of TTF-1 increases and the expression level of galectin-3 decreases in the pleural fluid sediment embedded tissues of lung adenocarcinoma patients, the combined detection of TTF-1 and galectin-3 has important clinical application value in the diagnosis of primary lung adenocarcinoma cells and differential diagnosis of metastatic cancer.
