A single-center retrospective study of relationship between 25 hydroxyvitamin D3 level and global registry of acute coronary event score in elderly patients with acute coronary syndrome
10.3760/cma.j.cn115455-20230408-00349
- VernacularTitle:高龄急性冠状动脉综合征患者25羟基维生素D3水平与全球急性冠状动脉事件注册评分相关性的单中心回顾性研究
- Author:
Hairui SHAO
1
;
Chenxi SHEN
;
Yao LI
;
Jingyu WANG
;
Ying LIU
;
Lei LYU
Author Information
1. 东部战区总医院干部二科心脏内科病区，南京 210002
- Keywords:
25 hydroxyvitamin D3;
Aged, 80 and over;
Coronary artery disease;
Global registry of acute coronary event score
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(10):893-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relation between 25 hydroxyvitamin D3 level and global registry of acute coronary event (GRACE) score in elderly patients with acute coronary syndrome (ACS).Methods:The clinical data of 120 elderly male patients with ACS hospitalized in the General Hospital of Eastern Theater Command from January 2020 to June 2022 were retrospectively analyzed. Clinical characteristics of patients were collected and the 25 hydroxyvitamin D3 level was assessed with the chemiluminescent immunoassay method. According to GRACE score, the patients were divided into intermediate-risk group (109 to 140 scores, 46 cases) and high-risk group(>140 scores, 74 cases). The severity of coronary lesion was assessed according to the results of coronary angiography (CAG) and then they were divided into A, B, C group. The independent influential factors of GRACE score were analyzed by Logistic regression analysis.Results:The level of 25 hydroxyvitamin D3 in the high-risk group was lower than that in the intermediate-risk group: (13.84 ± 3.42) μg/L vs. (18.57 ± 5.17) μg/L, the usage rate of angiotensin-converting enzyme inhibitors (ACEI)/angiotonin receptor blocker (ARB) in the high-risk group was lower than that in the intermediate-risk group: 17.6%(13/71) vs. 41.3%(19/46), there were statistical differences ( P<0.05). Logistic regression analysis showed that 25 hydroxyvitamin D3 level was the risk factor for GRACE score ( OR = 0.745, 95% CI 0.657-0.844, P<0.05). The level of 25 hydroxyvitamin D3 had negative correlation with the severity of coronary lesion ( P<0.05). Conclusions:The level of 25 hydroxyvitamin D3 has correlation with GRACE score and the severity of coronary lesion in elderly patients with ACS.
