A Case of Lichenoid Drug Eruption with Whole Body and Oral Mucosal Involvement Caused by Antituberculosis Drugs.
- Author:
Chan Ho NA
1
;
Hyun Deok SEO
;
Byoung Soo CHUNG
;
Bong Seok SHIN
Author Information
1. Department of Dermatology, Chosun University Medical School, Gwangju, Korea. derm75@chosun.ac.kr
- Publication Type:Case Report
- Keywords:
Antituberculosis drugs;
Lichenoid drug eruption
- MeSH:
Dermis;
Drug Eruptions;
Eosinophils;
Epidermis;
Ethambutol;
Humans;
Hydrazines;
Hyperpigmentation;
Lichen Planus;
Lip;
Middle Aged;
Mouth Mucosa;
Parakeratosis;
Rifampin;
Skin;
Weights and Measures
- From:Korean Journal of Dermatology
2008;46(8):1145-1148
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lichenoid drug eruption can arise as a result of exogenous compound exoposures and closely mimic idiopathic lichen planus. A 45-year-old man who had taken antituberculosis drugs (isoniazid, rifampin, ethambutol, pyrazinamide) for 2 months developed pruritic violaceous papules and plaques with silvery scales on the whole body. On close inspection, he had superficial erosions on the lips and reticulate white papules on the buccal mucosa. Histopathologic findings were hyperkeratosis, parakeratosis, and hypergranulosis in the epidermis and band-like lymphohistiocytic infiltration, numerous eosinophils, and perivascular lymphohistiocytic infiltration in the dermis. The skin lesions improved leaving hyperpigmentation after cessation of the antituberculosis drugs and application of topical corticosteroid.
