Exploring the changes of ultrasound elastography parameters, liver fibrosis index and clinical significance before and after cirrhosis treatment
10.3760/cma.j.cn115455-20230609-00630
- VernacularTitle:肝硬化治疗前后超声弹性成像参数、肝纤维化指标改变及临床意义探究
- Author:
Deli MENG
1
;
Fengfeng DING
;
Feng DING
Author Information
1. 绍兴文理学院附属医院超声科，绍兴 312000
- Keywords:
Liver cirrhosis;
Ultrasonography;
Risk factors;
Forecasting
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(8):688-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of ultrasound elastography parameters, liver fibrosis index and clinical significance before and after cirrhosis treatment.Methods:One hundred and eight patients with cirrhosis admitted to Affiliated Hospital of Shaoxing University of Arts and Sciences from April 2020 to May 2022 were selected retrospectively and divided into effective group and ineffective group according to the treatment effect, the liver function indexes and ultrasound parameters before and after treatment were compared, the correlation between ultrasound parameters and liver function index were analyzed by Pearson test, the risk factors influencing the efficacy were analyzed by Logistic regression, ultrasound parameters, liver fibrosis index parameters to predict the efficacy value were analyzed by the receiver operating characteristic (ROC) curve.Results:The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil) in the effective group were decreased and the level of ALB was increased after treatment: (83.38 ± 13.29) U/L vs. (112.84 ± 16.07)U/L, (72.65 ± 11.33) U/L vs. (90.75 ± 12.34) U/L, (33.82 ± 8.86) μmol/L vs. (41.49 ± 9.57) μmol/L, (38.44 ± 3.59) g/L vs. (33.84 ± 4.57) g/L, there were statistical differences ( P<0.05). The levels of liver stiffness measurement (LSM) maximum value (LSM max), minimum value (LSM min), mean value (mLSM), ultrasound semi-quantitative score, and fibrosis index based on the 4 factor (FIB-4) in the effective group after treatment were decreased: 20.80(12.00, 31.50) kPa vs. 26.50(15.20, 35.30) kPa, 4.40(3.10, 8.50) kPa vs. 6.50(3.20, 9.10) kPa, 14.80(10.10, 25.40) kPa vs. 20.00(13.00, 30.50) kPa, (7.79 ± 1.84) scores vs. (10.35 ± 2.61) scores, 3.11 ± 0.36 vs. 3.65 ± 0.48, there were statistical differences ( P<0.05). The results of Pearson test showed that LSM max, LSM min, mLSM, ultrasound semi-quantitative scores were positively correlated with AST, ALT, TBil, FIB-4, and negatively correlated with ALB ( P<0.05). The results of Logistic regression showed that after correcting for AST, ALT, TBil, ALB, the LSM max, LSM min, mLSM, ultrasound semi-quantitative score, and FIB-4 were still relevant influences on efficacy ( P<0.05). The results of ROC curve analysis showed that the area under the curve (AUC) of LSM max + LSM min + mLSM + ultrasound semi-quantitative score + FIB-4 predicting efficacy was greater than the AUC of liver function index combined ( P<0.05). Conclusions:The changes of ultrasound elastography parameters and liver fibrosis index before and after treatment are related to the outcome of cirrhosis treatment and have good correlation with the improvement of liver function.
