The relationship of multi-slice CT findings and epidermal growth factor receptor, kirsten rat sarcoma viral oncogene and survival outcome in patients with isolated lung adenocarcinoma
10.3760/cma.j.cn115455-20230306-00211
- VernacularTitle:孤立性肺腺癌患者多层螺旋CT表现与表皮生长因子受体、鼠类肉瘤病毒癌基因及生存结局关系探究
- Author:
Xupeng DONG
1
;
Jingjing ZHANG
;
Qiang ZHANG
Author Information
1. 秦皇岛市第一医院CT科，秦皇岛 066000
- Keywords:
Adenocarcinoma of lung;
Solitary pulmonary nodule;
Tomography, spiral computed;
Epidermal growth factor receptor;
Kirsten rat sarcoma viral oncogene;
Progn
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(6):508-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of multi-slice CT (MSCT) findings and epidermal growth factor receptor (EGFR), kirsten rat sarcoma viral oncogene (KRAS) and survival outcome in patients with isolated lung adenocarcinoma.Methods:The clinical data of 120 patients with solitary lung adenocarcinoma treated in the First Hospital of Qinhuangdao from January 2019 to September 2021 were collected retrospectively, the MSCT findings were analyzed, the correlationship of MSCT findings and EGFR, KRAS were analyzed by Spearman correlation, the MSCT findings of patients with different prognosis were compared, the prognostic risk factors were analyzed by Cox proportional risk model. A decision curve was drawn to analyze the net return of MSCT findings and biological factors combined to predict the prognosis of patients with isolated lung adenocarcinoma.Results:The MSCT findings results of 120 patients of isolated lung adenocarcinoma showed that the tumor diameter was (16.22 ± 3.31) mm, 88 patients with lobed signs, 74 patients with burr signs, 16 patients with vascular cluster signs, 76 patients with pleural indentation signs, 12 patients with cystic cavity changes, 75 patients with pure ground glass density shadows, 45 patients with mixed ground glass density shadows, 67 patients with round or almost round, and 53 patients with irregular shapes. There were positive correlation between MSCT findings (lobed signs, burr signs, pleural indentation signs, and cystic cavity changes) and EGFR and KRAS status in patients with isolated lung adenocarcinoma ( P<0.05). After 12 months of follow-up, 4 patients were lost, 96 patients survived and 20 patients died. The results of Cox proportional risk model analysis showed that lobed signs, pleural indentation signs, EGFR and KRAS mutants were high risk factors for death in patients with isolated lung adenocarcinoma ( P<0.05). The results of decision curve analysis showed that when the threshold value was 0.1 - 0.5, the model combined with lobed signs, pleural indentation signs, EGFR and KRAS status predicted the net death rate was better than the prediction value of simple indicators. Conclusions:MSCT findings in patients with isolated lung adenocarcinoma is closely related to EGFR and KRAS status, and the combination of these three factors has a higher net return in predicting prognosis, which is conductive to guiding clinical treatment and prognosis evaluation.
