Design of portable collection device for exhaled breath condensate
10.19745/j.1003-8868.2024150
- VernacularTitle:便携式呼出气冷凝液采集装置的设计
- Author:
An XIANG
1
;
Lei ZHOU
;
Qi-Feng JI
;
Yuan-Zhe LI
;
Qin WANG
;
Shi-Man ZHU
;
Jie PENG
;
Xiao-Ying LEI
;
Wei-Na LI
;
Li WANG
;
Yan-Hai GUO
;
Zi-Fan LU
Author Information
1. 空军军医大学药学系,西安 710032
- Keywords:
exhaled breath condensate;
portable collection device for exhaled breath condensate;
condenser;
respiratory tract infection
- From:
Chinese Medical Equipment Journal
2024;45(8):32-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a portable collection device of human exhaled breath condensate(EBC)based on natural breathing to meet the needs for rapid screening of human respiratory tract(especially lower respiratory tract)infections.Methods The device consisted of a refrigeration unit,a heat dissipation unit and a condensation unit.The refrigeration unit adopted a TES1-7102 thermoelectric Peltier cooler semiconductor as the refrigeration element;the heat dissipation unit was composed of a high thermal conductivity aluminum heat sink and a high-speed brushless cooling fan;the condensation unit was made up of a cold guide plate and a condenser,in which the cold guide plate was made of thin sheet of aluminum alloy,and the condenser was prepared by 3D printing technology and made of hydrophobic polylactic acid,with primary and secondary 2-stage guide grooves and an ultra-thin condensing surface.The performance of the device was verified in terms of cooling,thermal conductivity,condensation and human EBC collection and content analysis.Results Performance analysis showed that after refrigeration began the temperature difference between the condenser surface and the exhaled gas met the requirements of the condenser,and no obvious thermal resistance was found on the condensing surface so that large droplets could be formed rapidly and then be collected after the gas-liquid phase change of the exhaled gas on the condensing surface.Human EBC collection and content analysis indicated the device realized home self-collection of EBCs from people of all ages,and the concentrations of interleukins,C-reactive protein and other inflammation-related indexes and the pH value of the collected EBC samples were all correlated with respiratory infections in the subjects.Conclusion The device developed with easy operation avoids the discomfort of blowing collection and the risk of saliva contamination,and is worthy promoting for rapid diagnosis and dynamic monitoring of respiratory tract infection and other related diseases.[Chinese Medical Equipment Journal,2024,45(8):32-37]
