Influencing factors and research progress in the mouse model of myopia
10.3760/cma.j.cn115989-20240108-00011
- VernacularTitle:小鼠近视模型的影响因素及研究进展
- Author:
Susu LIU
1
;
Menghai SHI
;
Hongmin ZHANG
Author Information
1. 河南省人民医院 河南省立眼科医院 河南省眼科学与视觉科学重点实验室 郑州大学人民医院眼科，郑州 450003
- Keywords:
Myopia;
Mouse;
Refractive development;
Form deprivation;
Optical defocus;
Refraction;
Axial length, eye
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(11):1065-1072
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the high prevalence of myopia has become a global public health concern.Understanding the mechanism will help to achieve precise prevention and treatment of myopia.Animal models are important tools for studying the pathogenesis and prevention strategies.Mice are commonly used in myopia research, because they are easy to breed, feed and genetically manipulate.However, their small eye size makes it difficult to accurately measure the changes in biological parameters such as refraction and axial length.In addition, the refractive developmental pattern of mice is opposite to that of humans.This article reviews the structural features of the mouse cornea, lens, vitreous body, retina and sclera, the pattern of refractive development, and the latest progress about the establishment and evaluation of murine myopia models to provide some hints and references for further research.
