Research progress of exosomes in noninfectious uveitis
10.3760/cma.j.cn115989-20211022-00574
- VernacularTitle:外泌体在非感染性葡萄膜炎中的研究进展
- Author:
Zijia LIU
1
;
Yuanyuan GONG
Author Information
1. 上海交通大学医学院附属第一人民医院眼科，上海 200080
- Keywords:
Noninfectious uveitis;
Exosome;
Immunity;
Inflammation
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(11):1043-1047
- CountryChina
- Language:Chinese
-
Abstract:
Noninfectious uveitis (NIU) is a refractory disease that could lead to blindness.Lack of specific NIU indicators sometimes causes a delay in diagnosis and treatment, due to its diverse etiology, complex mechanism, and the long course of disease.Empirically, the clinical emphasis is to optimize diagnosis and treatment methods and reduce complications.Recent studies on exosomes have shown their regulatory effect on inflammation, suggesting that they have application potential in the diagnosis and treatment of uveitis.Exosomes are cell-derived cystic vesicles, containing a variety of effector biomolecules and biomarkers.They can penetrate biological barriers, mediate intercellular communication, and be used as drug carriers in clinical treatment.However, research on exosomes in fundus diseases, especially in uveitis, is still in its infancy.This article reviews advanced research, hypothesis, and possible translational applications of exosomes in NIU to provide new ideas for the diagnosis and treatment of the disease.
