Research progress on the relationship between activation of retinal glial cells and glaucoma
10.3760/cma.j.cn115989-20201216-00846
- VernacularTitle:神经胶质细胞反应性活化与青光眼疾病关系的研究进展
- Author:
Weiling BAI
1
;
Ningli WANG
;
Hanruo LIU
Author Information
1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室，北京 100730
- Keywords:
Glial cell;
Astrocyte;
Müller cell;
Microglial cell;
Glaucoma
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(9):862-865
- CountryChina
- Language:Chinese
-
Abstract:
Glial cells in the mammalian retina include macroglia and microglia.The role of glial cells in the glaucomatous disease process involves morphological changes, dynamic migration, and secretion of reactive factors.Activation of retinal glial cells can regulate the progression of glaucoma at the molecular level and affect the extracellular matrix and structural mechanics.Integrative bioinformatics analysis has been used to discover three core gene modules of astrocytes for the effect of glaucoma with high intraocular pressure.Studies have confirmed that mutations leading to glial cell abnormalities can influence the progression of glaucoma-like lesions in the retina.In terms of imaging, the emergence of new technologies has provided new research directions for in vivo observation of the reactive activation state of glial cells.This article reviews the role of glial cell activation in glaucoma with the aim of providing new directions for the pathogenesis and treatment of glaucoma.
