Research advances in the role of the cGAS-STING signaling pathway in eye diseases
10.13389/j.cnki.rao.2024.0188
- VernacularTitle:cGAS-STING信号通路在眼科疾病中的作用研究进展
- Author:
Yuyu XUE
1
;
Lu YE
;
Hejiang YE
Author Information
1. 610075 四川省成都市,成都中医药大学
- Keywords:
cGAS-STING;
eye diseases;
keratitis;
age-related macular degeneration;
diabetic retinopathy
- From:
Recent Advances in Ophthalmology
2024;44(12):999-1004
- CountryChina
- Language:Chinese
-
Abstract:
The cGAS-STING signaling pathway plays a crucial role in innate immunity,forming a monitoring system for tissue injury and pathogen invasion.Recent studies have found that the cGAS-STING signaling pathway may mediate a vari-ety of pathological processes in eyes and participate in the occurrence and development of inflammatory,degenerative eye diseases and ocular tumors,such as keratitis,age-related macular degeneration,diabetic retinopathy,and uveal melano-ma.This review aims to summarize the role of the cGAS-STING signaling pathway in eye diseases and elucidate the poten-tial molecular mechanisms of the cGAS-STING signaling pathway in eye diseases,so as to provide innovative approaches to the treatment of eye diseases.
