Recent advances in the study of neuroimmune inflammation and glaucoma pathogenesis
10.13389/j.cnki.rao.2024.0185
- VernacularTitle:神经免疫炎症与青光眼发病机制研究新进展
- Author:
Xiaotong WANG
1
;
Jianmei LI
;
Zhanglong LI
;
Bin GUO
;
Ping ZHAO
Author Information
1. 250014 山东省济南市,山东中医药大学眼科与视光医学院
- Keywords:
glaucoma;
retina;
central nervous system;
peripheral immune system;
inflammatory factor
- From:
Recent Advances in Ophthalmology
2024;44(12):986-991
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is a neurodegenerative disease characterized by progressive and irreversible necrosis and apopto-sis of retinal ganglion cells.The abnormal activation of microglia,astrocytes and Müller cells in the central nervous system of the retina and macrophages,T/B lymphocytes and regulatory T cells in the peripheral immune system is involved in the pathogenesis of glaucoma,and the secretion of inflammatory factors such as interleukin 6 and interleukin 8 is closely relat-ed to the development of glaucoma.In this paper,the role of immune cells of the central nervous system and peripheral im-mune system of the retina and the inflammatory factors they secreted in the development of glaucoma is reviewed,in order to understand the pathogenesis of glaucoma at the cellular and molecular levels and to provide ideas for exploring new treatment methods.
