Causal relationship between sex steroid hormones and myopia:a Mendelian randomization study
10.13389/j.cnki.rao.2024.0181
- VernacularTitle:性类固醇激素与近视之间的因果关系:一项孟德尔随机化研究
- Author:
Baohua LI
1
;
Zefeng KANG
;
Mingming ZHANG
;
Xinyue HOU
;
Jianquan WANG
;
Danyu LI
;
Mengyu LIU
;
Yipeng SHI
Author Information
1. 100040 北京市,中国中医科学院眼科医院
- Keywords:
Mendelian randomization;
myopia;
sex steroid hormone;
sex hormone-binding globulin;
testosterone;
estradiol
- From:
Recent Advances in Ophthalmology
2024;44(12):961-966
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causal relationship between serum sex steroid hormone levels and myopia with the Mendelian randomization(MR)methods.Methods Sex hormone genetic tools classified by sex were publicly availa-ble summarized statistical data from the Genome-wide association study(GWAS)of the UK Biobank Consortium on sex hormone-binding globulin(SHBG),total testosterone(TT),bioavailable testosterone(BT),and estradiol(E2).The GWAS summarized statistical data for myopia were obtained from publicly available data published by the FinnGen Consorti-um R10.All data were downloaded from April 18 to April 31,2024 from the corresponding databases and analyzed.All re-sults from the MR study were mainly analyzed by inverse-variance weighting(IVW)method.Results The study showed that a higher serum SHBG level in European increased the risk of myopia development in women(IVW,OR=1.152,95％CI:1.014-1.308,P=0.029);low serum TT level(IVW,OR=0.821,95％CI:0.697-0.967,P=0.018)and serum BT lev-el(IVW,OR=0.820,95％CI:0.691-0.972,P=0.022)increased the risk of myopia development in women.There was no causal relationship between serum SHBG,TT,and BT levels and myopia in men.There was no causal effect between E2 level and myopia in women and men.The stability of our findings was supported by sensitivity analysis.Conclusion In-creased serum SHBG level and decreased serum TT and BT levels are associated with an increased risk of myopia in women,whereas no such association is found in men.There is no causal relationship between E2 and myopia.
