Latest research advances in pathogenesis and potential therapeutic targets of diabetic retinopathy
10.13389/j.cnki.rao.2024.0145
- VernacularTitle:糖尿病视网膜病变发病机制及潜在治疗靶点研究最新进展
- Author:
Qiuping LIU
1
;
Zhaolin LIU
;
Jingming LI
Author Information
1. 421001 湖南省衡阳市,南华大学附属第一医院眼科
- Keywords:
diabetic retinopathy;
inflammation;
epigenetic modification;
mitochondrial damage;
retinal neurodegen-eration;
oxidative stress and nitrosative stress;
microvascular dysfunction;
genetic polymorphism
- From:
Recent Advances in Ophthalmology
2024;44(10):757-768
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of diabetes mellitus is increasing globally,which has contributed to a surge in diabetic reti-nopathy(DR)patients.DR has become the leading cause of visual impairment and blindness in the working-age popula-tion.The progressive development of DR involves many molecular and biochemical mechanisms,which interact with each other to affect the homeostasis of retinal blood vessels and cells.With the further study of the pathogenesis of DR,more and more molecular targets have been discovered.Studying the pathogenesis of DR and seeking potential therapeutic targets are of great clinical significance for the early prevention and treatment of DR and the prevention of its progression.In this paper,the latest developments in pathogenesis and potential therapeutic targets of DR are briefly reviewed.
