Research progress on the role of melatonin in diabetic retinopathy
10.13389/j.cnki.rao.2024.0126
- VernacularTitle:褪黑素在糖尿病视网膜病变中的作用研究进展
- Author:
Jianfeng LI
1
,
2
,
3
;
Lingqi YANG
;
Yang LÜ
Author Information
1. 730050 甘肃省兰州市,中国人民解放军联勤保障部队第九四○医院眼科中心
2. 730000 甘肃省兰州市,甘肃中医药大学第一临床医学院
3. 730050 甘肃省兰州市,中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃省干细胞与基因药物重点实验室
- Keywords:
melatonin;
diabetic retinopathy;
oxidative stress;
inflammation;
autophagy
- From:
Recent Advances in Ophthalmology
2024;44(8):658-662
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a common metabolic disease worldwide,which may cause oxidative damage,inflamma-tion,and impaired autophagy under prolonged high-glucose stimulation,resulting in the destruction of the blood-retinal barrier and then diabetic retinopathy(DR).Melatonin is a hormone secreted mainly by the pineal gland and to a lesser ex-tent by the retina,which not only has antioxidant activity,but is also involved in anti-inflammation,anti-tumor,immuno-modulation,modulation of autophagy,and neuroprotection.Melatonin functions well in controlling blood glucose and can attenuate high glucose-induced oxidative stress and apoptosis in retinal Müller cells.Moreover,melatonin protects mito-chondria,reduces neuronal damage,participates in anti-inflammatory and anticancer activities,and affects neovascularization by regulating autophagy and miRNA expression in endothelial progenitor cells.This review summarizes the role of melatonin in DR and elucidates the factors associated with melatonin regulation of DR,providing new ideas for the treatment of DR.
