Correlation between baseline aqueous humor cytokines and optical coherence tomography angiography changes after anti-vascular endothelial growth fac-tor treatment for macular edema secondary to retinal vein occlusion
10.13389/j.cnki.rao.2024.0103
- VernacularTitle:视网膜静脉阻塞继发黄斑水肿抗VEGF治疗后OCTA指标变化与基线房水细胞因子的相关性分析
- Author:
Jiaqin CHEN
1
;
Ying HUANG
;
Jin YAO
Author Information
1. 210000 江苏省南京市,南京医科大学眼科医院
- Keywords:
retinal vein occlusion;
macular edema;
cytokines;
fovea avascular zone
- From:
Recent Advances in Ophthalmology
2024;44(7):536-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between baseline aqueous humor cytokines and optical coher-ence tomography angiography(OCTA)changes in eyes with macular edema secondary to retinal vein occlusion(RVO-ME)after anti-vascular endothelial growth factor(VEGF)treatment.Methods From October 2021 to January 2023,30 eyes of 30 patients diagnosed with RVO-ME at the Affiliated Eye Hospital of Nanjing Medical University were included in this study.All eyes were treated with the intravitreal injection of anti-VEGF drugs once a month for 3 consecutive months and then treated as needed.The aqueous humors before the first and third injections were collected.The expression levels of VEGF,interleukins(IL),γ-interferon(IFN-y),intercellular adhesion molecule-1(ICAM-1),and platelet-derived growth factor(PDGF)were detected using the Luminex platform.The central macular thickness(CMT),fovea avascular zone(FAZ)area,perimeter(PERIM),acircularity index(AI),and the vessel density in a 300 μm wide region around FAZ(FD-300)were measured using OCTA.The best corrected visual acuity(BCVA)was examined using the international standard logarithmic visual acuity chart,which was converted into the logarithm of the minimum angle of resolution(log-MAR)for statistics.Aqueous humor cytokines and OCTA parameters were compared before and after anti-VEGF treatment for RVO-ME,and the relationship between OCTA changes(the difference between before and after treatment)and baseline aqueous humor cytokines was analyzed.Results After treatment,the levels of VEGF,ICAM-1,PDGF,IL-8,and IL-10 in RVO-ME patients decreased(all P＜0.05),the BCVA improved(P＜0.001),and CMT,AI and FD-300 decreased(all P＜0.05).Correlation analysis results showed that baseline IL-13 was negatively correlated with the AI change(r=-0.388,P＜0.05),and baseline IL-8 was negatively correlated with the FD-300 change(r=-0.421,P＜0.05).Conclusion Baseline IL-13 and IL-8 may be related to the improvement of the retinal macular microvascular structure after anti-VEGF treatment for RVO-ME.For the treatment and management of RVO-ME,in addition to anti-VEGF therapy,targeted anti-in-flammatory therapy should also be considered.
