Advances in ocular surface and intestinal flora of patients with thyroid-asso-ciated ophthalmopathy
10.13389/j.cnki.rao.2024.0095
- VernacularTitle:甲状腺相关性眼病患者眼表及肠道菌群的研究进展
- Author:
Xiran ZHANG
1
;
Xinxin ZHANG
;
Zhiming KANG
;
Kui DONG
;
Bin SUN
Author Information
1. 030001 山西省太原市,山西医科大学第一临床医学院
- Keywords:
thyroid-associated ophthalmopathy;
intestinal flora;
ocular surface flora;
gut-eye axis
- From:
Recent Advances in Ophthalmology
2024;44(6):494-498
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid-associated ophthalmopathy(TAO)is an autoimmune disease whose etiology and pathogenesis have not yet been clarified.It is generally believed that its occurrence is the result of a combination of immune,genetic,envi-ronmental,and other factors.In recent years,scholars have paid more attention to the influence of microorganisms on TAO,and they found that alterations of the ocular surface and intestinal flora can stimulate the immune system to generate a series of immune responses,which induces autoimmune responses to TAO.The"gut-eye axis"may be an important fac-tor involved in the development of TAO.The intestinal flora and its metabolites may affect ocular tissues through blood cir-culation and the lymphatic system.This interaction between the gut and eye axis may affect the occurrence and develop-ment of TAO through various pathways,including migration of immune cells,cross immune reactions,and metabolite cir-culation.This article reviews the research progress on the correlation between alterations of the ocular surface and intesti-nal flora and TAO and explores the possible mechanisms of the flora involvement in the development of TAO,providing new ideas for the diagnosis and treatment of TAO.
