Expressions of β-catenin/transcription factor 4 signaling pathway-related proteins in colon cancer tissues and their relationship with postoperative recurrence and metastasis
10.7683/xxyxyxb.2024.11.012
- VernacularTitle:结肠癌组织中β-连环蛋白/转录因子4信号通路相关蛋白表达及其与患者术后复发转移的关系
- Author:
Pengfei FENG
1
;
Huijie GONG
;
Jinglan HU
Author Information
1. 驻马店市中心医院消化一胃肠内科,河南 驻马店 463000
- Keywords:
colon cancer;
β-catenin/transcription factor 4;
signaling pathway;
recurrence and metastasis
- From:
Journal of Xinxiang Medical College
2024;41(11):1065-1069
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of the β-catenin/transcription factor 4(TCF4)signaling pathway-related proteins in colon cancer tissues and their relationship with postoperative recurrence and metastasis of colon cancer.Methods A total of 86 patients with colon cancer admitted to Zhumadian Central Hospital from January 2020 to January 2022 were selected as the research subjects,all of whom underwent surgical resection of the colon.Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression levels of Wnt-1,β-catenin and TCF4 mRNA in cancer tissues and adjacent tissues of patients,and immunohistochemistry was used to detect the protein expression levels of Wnt-1,β-catenin and TCF4.The Cox proportional hazards regression model was used to analyze the risk factors of postoperative recurrence and metastasis of colon cancer.Results The relative mRNA expression levels and protein expression positive rates of Wnt-1,β-catenin and TCF4 in cancer tissues were significantly higher than those in adjacent tissues of colon cancer patients(P＜0.05).The expression positive rates of Wnt-1,β-catenin and TCF4 protein were correlated with the degree of tumor invasion,tumor stage and lymph node metastasis(P＜0.05),but not correlated with age,sex,tumor size and differentiation degree(P＞0.05).Cox regression analysis showed that lymph node metastasis,and positive protein expressions of Wnt-1,β-catenin and TCF4 were risk factors for postoperative recurrence and metastasis of colon cancer(P＜0.05).Conclusion The mRNA expression levels and protein expression positive rates of Wnt-1,β-catenin and TCF4 are higher in colon cancer tissues.The protein expression positive rates of Wnt-1,β-catenin and TCF4 are significantly correlated with the degree of tumor invasion,tumor stage and lymph node metastasis,and are risk factors for postoperative recurrence and metastasis of colon cancer.
