Research progress of glutathione peroxidase 4/glutathione ferroptosis defense system in the treatment of triple-negative breast cancer
10.7683/xxyxyxb.2024.10.017
- VernacularTitle:谷胱甘肽过氧化物酶4/谷胱甘肽铁死亡防御系统在三阴性乳腺癌治疗中的作用研究进展
- Author:
Yuan ZHOU
1
;
Yang LYU
;
Xuerui LI
;
Xiaoyue YANG
;
Jiaqi SONG
;
Huixia LU
Author Information
1. 大理大学临床医学院,云南 大理 671013
- Keywords:
ferroptosis;
triple-negative breast cancer;
glutathione;
glutathione peroxidase 4
- From:
Journal of Xinxiang Medical College
2024;41(10):991-995
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a way of cell death with lipid peroxides as the core.Cells can reduce ferroptosis sensitivity by relying on glutathione peroxidase 4(GPX4)/glutathione(GSH)antioxidant systems.Triple-negative breast cancer(TNBC)cells are more dependent on the intracellular antioxidant mechanism than normal cells,thus induction of ferroptosis based on the GPX4/GSH system has shown bright anti-TNBC prospects.This paper reviews the recent research on TNBC treatment with ferroptosis in the background of GPX4/GSH,in order to provide references for the clinical treatment of TNBC.
