Research progress on the relationship between intestinal mucosal barrier and acute-on-chronic liver failure
10.7683/xxyxyxb.2024.08.017
- VernacularTitle:肠道黏膜屏障与慢加急性肝衰竭的关系研究进展
- Author:
Li ZHANG
1
;
Zhaolian BIAN
;
Hong XUE
Author Information
1. 南通大学医学院,江苏 南通 226001
- Keywords:
acute-on-chronic liver failure;
intestinal mucosal barrier;
microbial barrier;
intestinal microbiota;
therapeutic modalities
- From:
Journal of Xinxiang Medical College
2024;41(8):793-797,封3
- CountryChina
- Language:Chinese
-
Abstract:
The gastrointestinal tract is an extremely complex ecosystem,and a healthy and intact intestinal mucosal barrier is the basic defense against the translocation of harmful substances.The impaired function of the intestinal barrier in acute-on-chronic liver failure(ACLF)is further aggravated by the dysregulation of intestinal microecology,which leads to bacterial translocation and endotoxemia.Maintaining the normal function of the intestinal mucosal barrier is important for the treatment of ACLF.This paper reviews the function of the normal intestinal mucosal barrier,the relationship between the damaged intestinal barrier and ACLF,and the impact of the damaged intestinal barrier on ACLF progression.
