Correlation between cognitive impairment and event-related potential P300 in patients with acute ischemic stroke-related obstructive sleep apnea
10.7683/xxyxyxb.2024.07.009
- VernacularTitle:急性缺血性脑卒中相关阻塞性睡眠呼吸暂停患者认知功能损害与事件相关电位P300的相关性
- Author:
Wen WANG
1
;
Zhenyun BI
Author Information
1. 河北省沧州中西医结合医院神经内科,河北 沧州 061000
- Keywords:
acute ischemic stroke;
obstructive sleep apnea;
cognitive impairment;
event-related potential P300
- From:
Journal of Xinxiang Medical College
2024;41(7):651-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the corr-elation between cognitive impairment and event-related potential P300 in patients with acute ischemic stroke-related obstructive sleep apnea(OSA).Methods A total of 114 patients with acute ischemic stroke-related OSA admitted to the Department of Neurology of Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei from January 2022 to August 2023 were selected as the research subjects.Patients with cognitive impairment were included in the observation group(n=38),and patients without cognitive impairment were included in the control group(n=76).A standardized mini-mental state examination(MMSE)was used to test the cognitive function of patients in the two groups,and the MMSE scores of patients in the two groups were compared.The brain regions affected by infarct lesions of patients in the two groups were examined by using cranial magnetic resonance diffusion-weighted imaging and magnetic resonance imaging.The SC-500 non-contact,non-intrusive sleep monitoring sensor mattress was used to screen and assess stroke-related OSA in the two groups.The American Nerosscan 64-channel 10/20 electroencephalographic system was employed to detect event-related potential P300 of patients in the two groups.Univariate and multivariate logistic regression analysis were conducted to examine the correlation between cognitive impairment and event-related potential P300 in patients with acute ischemic stroke-related OSA.Results The total MMSE score and the scores in each dimension,including orientation,immediate memory,attention and calculation,recall ability,and language ability of patients in the observation group were significantly lower than those in the control group(P＜0.05).Age,proportions with a history of diabetes,hyperhomocysteinemia,and apnea-hypopnea index(AHI)of patients in the observation group were significantly higher than those in the control group,while the years of education was significantly lower than that in the control group(P＜0.05).The proportions of patients with infarct lesions located in the frontal lobe,temporal lobe,parietal lobe,occipital lobe,thalamus,basal ganglia,brainstem,and centrum semiovale in the observation group were significantly higher than those in the control group(P＜0.05).The P300 latency in the prefrontal,central,and parietal regions of patients in the observation group was significantly longer than that in the control group(P＜0.05).The P300 amplitude in the central and parietal regions of patients in the observation group was significantly lower than that in the control group(P＜0.05).The results of multivariate logistic regression analysis indicated that the years of education was a protective factor against cognitive impairment in patients with acute ischemic stroke-related OSA(P＜0.05).Thalamic infarction,high AHI,and prolonged P300 latency in the parietal region were independent risk factors for cognitive impairment in patients with acute ischemic stroke-related OSA(P＜0.05).Conclusion Patients with acute ischemic stroke-related OSA are prone to cognitive impairment in multiple domains.The P300 latency in the parietal region is closely associated with cognitive impairment in patients with acute ischemic stroke-related OSA and serves as an independent risk factor for cognitive impairment in these patients.
