Research progress on 5-hydroxytryptamine in the pathogenesis of inflammatory bowel disease
10.7683/xxyxyxb.2024.05.015
- VernacularTitle:5-羟色胺在炎症性肠病发病机制中的作用研究进展
- Author:
Anna WEI
1
;
Hui WANG
Author Information
1. 新乡医学院第二临床学院,河南 新乡 453002
- Keywords:
5-hydroxytryptamine;
inflammatory bowel disease;
inflammatory reaction
- From:
Journal of Xinxiang Medical College
2024;41(5):482-485
- CountryChina
- Language:Chinese
-
Abstract:
5-hydroxytryptamine(5-HT)is a monoamine neurotransmitter,which plays a key role in regulating gastroin-testinal motility,antioxidation and immunomodulation.Inflammatory bowel disease(IBD)is characterized by repetitive epi-sodes of inflammation of the gastrointestinal tract,and its pathogenesis hasn't been illustrated completely.In recent years,the role of 5-HT in the development of IBD has drawn attention gradually.Therefore,this article reviews the advances of 5-HT in the pathogenesis of IBD and focuses on the pathways of autophagy,oxidative stress,inflammatory reaction,endoplasmic reticu-lum stress and gut microbiota through which 5-HT causes IBD,with the hope of providing insights for identifying novel prognos-tic biomarkers and exploring new therapies.
