Analysis of risk factors for hyperuricemia in patients with primary IgA nephropathy
10.7683/xxyxyxb.2024.05.004
- VernacularTitle:原发性IgA肾病患者伴发高尿酸血症危险因素分析
- Author:
Chahan·Suolinge
1
;
Jing LI
;
Mengyun LIU
Author Information
1. 新疆医科大学第一附属医院肾病二科,新疆 乌鲁木齐 830011
- Keywords:
hyperuricemia;
primary IgA nephropathy;
triglyceride
- From:
Journal of Xinxiang Medical College
2024;41(5):419-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors for hyperuricemia in patients with primary IgA nephropathy(IgAN).Methods A total of 186 patients with primary IgAN admitted to the Department of Nephrology of the First Affiliated Hospital of Xinjiang Medical University from March 2018 to February 2021 were selected as the research subjects.The patients were divided into the IgAN group(n=104)and IgAN with hyperuricemia group(n=82)according to the blood uric acid(UA)level.The clinical data of patients in the two groups were compared.Univariate and multivariate logistic regression were used to analyze the risk factors of IgAN with hyperuricemia,and Pearson correlation was used to analyze the relationship between blood UA levels and clinical indicators in patients with primary IgAN.Results The results of univariate analysis showed that there was no significant difference in gender,age,body mass index(BMI),blood albumin,plasma total protein,high-density lipoprotein,serum IgA,serum complement C3,and serum complement C4 between the two groups(P＞0.05).The systolic blood pressure(SBP),diastolic blood pressure(DBP),low-density lipoprotein,serum creatinine,total cholesterol,triglycerides,blood urea nitrogen,24-hour urine protein quantification,and blood UA level of patients in the IgAN with hyperuricemia group were significantly higher than those in the IgAN group,while hemoglobin and estimated glomerular filtration rate(eGFR)were significantly lower than those in the IgAN group(P＜0.05).Pearson correlation analysis showed that there was no significant association between primary IgAN with hyperuricemia and age,BMI,blood albumin,plasma total protein,high-density lipoprotein,serum IgA,and serum complement C3(r=-0.020,-0.067,-0.064,-0.037,-0.103,0.008,0.042,P＞0.05);primary IgAN with hyperuricemia was positively correlated with SBP,low-density lipoprotein,DBP,serum creatinine,total cholesterol,triglycerides,blood urea nitrogen,and 24-hour urine protein quantification(r=0.392,0.296,0.552,0.713,0.452,0.787,0.599,0.655,P＜0.05),and was negatively correlated with hemoglobin level,serum complement C4 level,and eGFR(r=-0228,-0663,-0516,P＜0.05).Multivariate logistic regression analysis showed that high SBP,DBP,triglyceride level,and blood UA level were independent risk factors for hyperuricemia in IgAN patients(P＜0.05).Conclusion High SBP,DBP,triglyceride level,and blood UA level are independent risk factors for hyperuricemia in patients with primary IgAN.
