Cardiovascular protective effects of SGLT-2 inhibitors on patients with type 2 diabetic nephropathy
10.3969/j.issn.1008-0074.2024.04.15
- VernacularTitle:SGLT-2抑制剂对2型糖尿病肾病患者的心血管保护作用
- Author:
Ya-Fei SANG
1
;
Jing-Ya YUAN
;
Qian ZHAO
;
Jia-Lin WANG
;
Yu-Jin MA
;
Hong-Yun WANG
Author Information
1. 河南科技大学第一附属医院内分泌科,河南洛阳 471003
- Keywords:
Diabetic nephropathies;
Sodium-glucose transporter 2;
Cardiovascular system
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):449-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy and cardiovascular protective effect of sodium-glucose co-transporter 2 inhibitor(SGLT-2i)on patients with type 2 diabetic nephropathy(T2DN).Methods:A total of 376 T2DN patients admitted in our Department of Endocrinology and Department of Cardiology from January 2018 to December 2021 were selected.According to therapeutic program,they were divided into control group(n=177,re-ceived routine treatment program)and SGLT-2i group(n=199,received SGLT-2i based on routine treatment program),both groups were continuously treated for 1 year.Blood glucose,blood pressure,blood lipids,uric acid,body mass index,renal function-related indexes and the occurrence of major adverse cardiovascular events were compared between the two groups after 12 months,as well as the adverse drug reactions.Results:After 12-month treatment,compared with control group,there were significant reductions in levels of blood pressure,fasting blood glucose(FBG),glycosylated hemoglobin A1e(HbA1c),urinary albumin/creatinine ratio(UACR),creatinine(Cr),blood urea nitrogen(BUN),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and uric acid(UA),and significant rise in estimated glomerular filtration rate(eGFR),levels of high density lipoprotein cholesterol(HDL-C),albumin(Alb)and alanine aminotransferase(ALT)in SGLT-2i group(P＜0.05 or＜0.01).Incidence rates of acute myocardial infarction(1.51％vs.6.21％)and heart failure caused-readmission(2.51％vs.6.78％)in SGLT-2i group were significantly lower than those of control group,and inci-dence rate of urinary system infection(8.54％vs.1.69％)was significantly higher than that of control group(P＜0.05 all).Conclusion:SGLT-2i can not only effectively control blood glucose,but also reduce body weight and blood pressure,improve blood lipids,reduce uric acid,improve renal hyperfiltration,reduce urinary protein and possess unique cardiovascular benefits,but risk of urinary system infection calls for attention.
